Research School: Digital Twins of the Human Body

Session

BIOMEDICAL MODELING SESSION

Dec 10, 2025, 9:45 AM

Room 128-129 (SISSA Main Building)

Conveners

BIOMEDICAL MODELING SESSION: The Mechanobiology of Cell Motility

• Alberto Salvadori (University of Brescia)

BIOMEDICAL MODELING SESSION: Poro-viscoelasticity of brain tissue: modeling and inverse parameter identification

• Alexander Greiner (FAU)

BIOMEDICAL MODELING SESSION: Modelling vascularized tissues: coupling 3D elastic matrix and 1D vascular tree

• Camilla Belponer (WIAS Berlin)

BIOMEDICAL MODELING SESSION: Computational Cardiac Models in the iHEART Simulator

• Luca Dedè (Politecnico di Milano)

15. The Mechanobiology of Cell Motility

Salvadori, Alberto (University of Brescia)

12/10/25, 9:45 AM

While the biochemistry of blood coagulation is well understood, less is known about how the mechanobiology of platelets influences clot remodeling and thus initiates tissue repair. Platelets not only release biochemical components needed to rapidly form fibrin-rich thrombi but also initiate wound site contraction. Research has shown that platelets are responsible for assembling the initial...

17. Poro-viscoelasticity of brain tissue: modeling and inverse parameter identification

Greiner, Alexander (FAU)

12/10/25, 11:00 AM

The brain is arguably the most complex human organ and modeling its mechanical behavior has challenged researchers for decades. There is still a lack of understanding on how this tissue responds to mechanical loading and how material parameters can be reliably calibrated. The Theory of Porous Media combined with finite viscoelasticity provides a theoretical framework to explore the underlying...

25. Modelling vascularized tissues: coupling 3D elastic matrix and 1D vascular tree

Belponer, Camilla (WIAS Berlin)

12/11/25, 2:00 PM

A key aspect of vascularized tissues is the fact that their properties are heavily influenced by the presence of the vascular tree. On one hand vessels are expanding and contracting due to systemic circulation on the other hand the surrounding matrix reacts with a counter-active (elastic) response. This means that neither the circulation at the capillaries, nor the elastic properties of the...

26. Computational Cardiac Models in the iHEART Simulator

Dedè, Luca (Politecnico di Milano)

12/11/25, 2:45 PM

In this talk, we review mathematical and numerical models of the human heart that are able to capture both its physiology and pathological conditions. We focus on the differential models underlying cardiac electrophysiology, mechanics, and blood flow dynamics, including those that describe the fiber bundles characteristic of cardiac tissue. We then present an overview of the numerical methods...