Olfactory receptors, chemical structure and animal models
- Marc Spehr
Prof. Andrea Buettner
10/6/17, 11:00 AM
Odor potency and odor character are obviously tightly linked to chemical structure. Numerous studies have shown that specific structural features such as thio groups or aromatic moieties bare a high potential of causing extremely low odor thresholds, and, accordingly, of inducing potent smells. Likewise, specific groups appear to be commonly associated with specific smell character such as...
7. From odors to brain: how odor binding is transduced into electrical signals traveling to the brain.
Dr Simone Pifferi (International School for Advanced Studies (SISSA), Trieste, Italy)
10/6/17, 11:20 AM
The initial steps of olfaction occur in olfactory sensory neurons located in the olfactory epithelium of the nasal cavity of vertebrates. These neurons are responsible for the detection of odorant molecules present in the surrounding environment and the generation of neural signals that are transmitted to the brain. Once an odor molecule binds to a receptor in the cilia of an olfactory sensory...
Ms Sara Joy Hawkins (Institute of Neurophysiology and Cellular Biophysics, University of Göttingen, Göttingen, Germany)
10/6/17, 11:40 AM
The olfactory system of Xenopus laevis tadpole is an optimal model to study the process of neuronal regeneration. Tadpoles are known for their elevated regenerative capacity, and the olfactory system exhibits lifelong cell turnover and a remarkable ability to recover even after severe lesion. By transecting the olfactory nerve we were able to observe and describe the events that occur as a...